Hydrogen Sulfide Inhibits Amyloid Formation
نویسندگان
چکیده
منابع مشابه
Hydrogen Sulfide Inhibits Amyloid Formation
Amyloid fibrils are large aggregates of misfolded proteins, which are often associated with various neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and vascular dementia. The amount of hydrogen sulfide (H2S) is known to be significantly reduced in the brain tissue of people diagnosed with Alzheimer's disease relative to that of healthy individuals. These findings prom...
متن کاملHydrogen sulfide inhibits plasma renin activity.
The development of renovascular hypertension depends on the release of renin from the juxtaglomerular (JG) cells, a process regulated by intracellular cAMP. Hydrogen sulfide (H2S) downregulates cAMP production in some cell types by inhibiting adenylyl cyclase, suggesting the possibility that it may modulate renin release. Here, we investigated the effect of H2S on plasma renin activity and BP i...
متن کاملHydrogen Sulfide Formation by Shigella alkalescens.
The Shigella are generally regarded as organisms that fail to form hydrogen sulfide. In a recent report on a lead semisolid agar, Friewer and Shaughnessy (Am. J. Clin. Path., 8, 1) observed the formation of H2S by several strains of Shigella paradysenteriae (Flexner) and Shigelka sonnei in this medium and also by the lead acetate paper test, although no mention was made of this reaction by Shig...
متن کاملCooperative hydrogen bonding in amyloid formation.
Amyloid diseases, including Alzheimer's and prion diseases, are each associated with unbranched protein fibrils. Each fibril is made of a particular protein, yet they share common properties. One such property is nucleation-dependent fibril growth. Monomers of amyloid-forming proteins can remain in dissolved form for long periods, before rapidly assembly into fibrils. The lag before growth has ...
متن کاملHydrogen sulfide inhibits the renal fibrosis of obstructive nephropathy
Hydrogen sulfide has recently been found decreased in chronic kidney disease. Here we determined the effect and underlying mechanisms of hydrogen sulfide on a rat model of unilateral ureteral obstruction. Compared with normal rats, obstructive injury decreased the plasma hydrogen sulfide level. Cystathionine-β-synthase, a hydrogen sulfide-producing enzyme, was dramatically reduced in the ureter...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physical Chemistry B
سال: 2015
ISSN: 1520-6106,1520-5207
DOI: 10.1021/jp508471v